Understanding Subdermal Injections: When to Use Them and How to Do Them Right at Home

25th Apr 2025

Understanding Subdermal Injections: When to Use Them and How to Do Them Right at Home

Administering medication at home has become increasingly common thanks to the growing availability of self-care tools and trusted medical supplies. Among the various injection types, subdermal injections (often called subcutaneous or “subcut” injections) offer a reliable way to deliver medication just under the skin’s surface. While they’re not as deeply inserted as intramuscular injections, they’re still incredibly effective—and when done correctly, they can be safe, comfortable, and highly accurate.

At Bulk Syringes, we provide the medical-grade syringes and tools people need to manage their care confidently at home.

What Is a Subdermal (Subcutaneous) Injection?

A subdermal injection delivers medication into the fatty tissue layer just beneath the skin. This layer absorbs medication more slowly than muscle tissue, making it ideal for drugs that require gradual release into the bloodstream.

These injections are commonly used for:

  • Insulin for diabetes

  • Hormone therapy (e.g., testosterone or estrogen)

  • Fertility medications

  • Blood thinners like heparin

  • Vitamin B12 supplements

  • Biologics for autoimmune conditions like rheumatoid arthritis or Crohn’s disease

Because subdermal injections are shallower than intramuscular injections, they’re often more comfortable and require shorter, finer needles.

Choosing the Right Syringes and Needles

The success of any injection starts with using the right tools. For subdermal injections, you’ll typically need:

  • Syringes with a fine needle: 26–31 gauge needles are ideal, with a length of about 3/8” to 5/8”. These are short enough to stay within the subcutaneous tissue without going too deep.

  • Volume-appropriate barrels: 1 mL or 3 mL syringes are common sizes, depending on your dosage.

  • Luer lock or slip tip syringes: Either type works depending on your comfort and how the needle is attached. Luer lock syringes offer more security for needle placement.

BulkSyringes.com offers sterile, individually wrapped syringes and needles so you can trust that your at-home injections are both safe and reliable.

How to Perform a Subdermal Injection at Home

Administering your own injection might feel intimidating at first, but with preparation and practice, it becomes a manageable part of your routine.

Step-by-step guide:

  1. Wash your hands thoroughly. Cleanliness is crucial to avoid infection.

  2. Gather your supplies: Medication vial, sterile syringe and needle, alcohol swab, and sharps container.

  3. Draw up the medication: Clean the vial top with an alcohol swab, insert the needle into the vial, and draw up the correct dose.

  4. Remove air bubbles: Tap the syringe gently and push the plunger slightly to remove air.

  5. Choose your injection site: Common areas include the abdomen (away from the navel), upper thighs, or the back of the upper arms.

  6. Clean the site with an alcohol swab.

  7. Pinch the skin to lift the fatty tissue away from the muscle.

  8. Insert the needle at a 45–90 degree angle, depending on the needle length and your body type.

  9. Inject slowly and steadily, then withdraw the needle and dispose of it in a sharps container.

  10. Apply light pressure with a cotton ball or tissue if needed—don’t rub the site.

Tips for Success and Comfort

  • Rotate injection sites to prevent tissue damage or soreness.

  • Use a mirror if you’re injecting into the back of the arm.

  • Warm the medication slightly in your hands before injecting to reduce stinging.

If you’re a caregiver administering injections, ensure the person receiving it is in a relaxed position, and always explain each step before you begin to help them feel comfortable and informed.

When to Contact a Healthcare Provider

While subdermal injections are generally safe, reach out to your provider if you notice:

  • Unusual redness, swelling, or pain at the injection site

  • Bleeding that doesn’t stop

  • Signs of infection

  • Difficulty drawing medication or using the syringe properly

Never hesitate to ask your healthcare provider or pharmacist for a walkthrough—especially when starting a new medication.

Moving Forward with Safe, Confident Care

Subdermal injections are an essential part of many at-home healthcare routines. When administered with care and the right supplies, they’re a safe and effective way to manage chronic conditions, hormone levels, or nutritional deficiencies.

At Bulk Syringes, we’re here to support your health with high-quality syringes, needles, and accessories that make home injection easier and more comfortable. Whether you’re caring for yourself or someone else, you can count on us to deliver the tools you need—discreetly, affordably, and reliably.